Human epididymis protein 4 indicates progression of cardiac fibrosis in Heart Failure with preserved Ejection Fraction
نویسندگان
چکیده
Abstract Background Cardiac fibrosis is one of the main causes diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF). Human epididymis protein 4 (HE4) a novel pro-fibrotic expressed especially activated fibroblast, so-call myofibroblast [1]. Although our previous study showed that HE4 functioned as secretory factor promoting cardiac dilated cardiomyopathy [2], little known about role HFpEF. Purpose The aim this to evaluate pathophysiological HFpEF and association between serum levels clinical course Methods In basic research, we administered high-fat diet NOS inhibitor (L-NAME) mice for 5 weeks induce We analyzed echocardiographic findings mRNA expressions fibrosis-related genes including by real time PCR. measured 79 patients divided these into low high group using median values (102.0 pmol/L). Then, evaluated their mortality cardiovascular events retrospectively. Results vivo, administration fat L-NAME induced significant increase left ventricular mass on echocardiography compared control (p=0.006). aSMA collagen3a1 tissue was upregulated model (p=0.008 p=0.003, respectively). Furthermore, expression also (n=6) than (n=5), although differences did not reach statistical significance (p=0.238). vitro, recombinant genes, such periostin (p=0.001), (p=0.037), (p=0.095), PAI-1 (p=0.17), indicating facilitate activation fibroblast some significance. Kaplan-Meier curve revealed rate all cause death rehospitalization worsening were significantly higher group, suggesting can predicts prognosis Conclusion induces fibroblasts mice. it useful biomarker predicting Funding Acknowledgement Type funding sources: None.
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.3011